It happened Wednesday at the Bancorp South branch on East Main Street.
Police say two black men armed with handguns walked into the bank and demanded money.
No one was hurt during the heist.
Police describe one of the men as being 6' tall and wearing a lime green t-shirt with dark pants. The other suspect is described as being 5'10" tall and wearing a lime green t-shirt with a white long sleeve undershirt.
Both suspects are considered armed and dangerous.
Anyone with information about the incident is urged to call the El Dorado Police Department at (870) 863-4141.