The deadly accident happened on Highway 167 north of Sheridan just before noon Saturday.
Two people in a Chevy Suburban, 53-year-old Willie Lewis and 13-year-old Ashley Lewis from Little Rock, died in the wreck, along with 51-year-old Virginia Gana and 52-year-old Ronald Gana from Newport.
The Ganas were in the other vehicle.
Two other young people -- a 13-year-old and a 17-year-old -- were riding in the Suburban and were hurt in the wreck.
The investigation is continuing.