Kathie Lee and Hoda will broadcast a show in early October from a college campus.
To enter your university, all you need to do is tweet with the hashtag #KLGandHodaU and mention your school.
The co-hosts invite everyone to "get our attention with creative and original messages and send us pictures and videos as well."
The six schools that demonstrate the most spirit will be named finalists, and then America will vote on which college they most want KLG and Hoda to visit.
Follow TODAY's fourth hour, Kathie Lee, Hoda and Sara Haines on Twitter to get all updates about the challenge.
The deadline is September 16th at 9:00 a.m.
Click here for the official rules.