It happened Sunday afternoon at the air strip at Gaston's Resort along the White River near Lakeview.
The Baxter County Sheriff's Office (BCSO) says the 911 Center received the call at about 2:30 PM.
Deputies say the pilot of a 2008 4 seat Cirrus CSR 22 aircraft was trying to take off from Gaston's.
The plane encountered difficulties and veered to the right. Each wing of the plane struck some trees, and the aircraft then traveled about 50 yards more and came to rest in some hedges near cabin no. 71.
The aircraft was registered to RTJ Aircraft, Inc. of Wilmington, Delaware.
The plane was being piloted by Jordan Smith, 30, of Kansas City, Missouri. His passengers were Matthew Stengel, 23, of Springfield, Missouri in the front and Casey Stengel, 28, in the back.
The plane sustained heavy damage, the BCSO said.
The Federal Aviation Administration was contacted, and representatives from that agency will be coming to the location to investigate the crash.