Loyce Durant Brown, 62, was last seen this morning around six o'clock.
The Lawrence County Sheriff's Office (LCSO) says Brown has dementia.
He is 5'10" tall and weighs 210 pounds.
Brown was last known to be at 2700 Highway 115, in Smithville, near Highway 115 and Highway 117.
The LCSO says he may be traveling in a red 2000 Chevrolet Z-71 4X4 extended cab pick-up truck with Arkansas license plate 370 HJZ.
If you think you've seen Brown, call the Lawrence County Sheriff's Office at (870) 886-2525.