Jurors delivered the verdict around 10 p.m. after deliberating for about 21 hours. There were convictions related to all 10 sexual abuse victims, with the three not-guilty verdicts applying to three different individuals.
Sandusky stood slightly hunched, looking down with his hand in his pocket but showing no visible emotion as the guilty verdicts were read out in court. His wife, Dottie, blinked back tears.
Judge John Cleland revoked Sandusky's bail and ordered his arrest. Video showed him leaving the courthouse in handcuffs and heading into an awaiting police car, again showing little emotion.
Sandusky's case gripped the nation and led to the dismissal of a legendary coach and one of America's highest-paid university presidents, while his trial included gripping and at times graphic testimony from his victims.
During closing arguments, prosecutors described the ex-Nittany Lions defensive coordinator as a pedophile who preyed on victims using a charity he founded for troubled children, repeatedly abusing young boys in his care.
Sandusky, 68, had pleaded not guilty to the 48 charges of child sex abuse that spanned a 15-year period.
His defense sought to poke holes in the prosecution's case throughout the trial, such as pointing to inconsistencies in the testimony of Mike McQueary, a former graduate assistant who testified that he witnessed Sandusky apparently sodomizing a boy in a university shower.
Defense attorney Joe Amendola reminded jurors of the lack of physical evidence in the case, accusing the alleged victims of conspiring for financial gain, while also blaming the media for what he described as biased coverage.
Lead prosecutor Joseph McGettigan rebuffed those arguments, telling jurors that "the commonwealth has overwhelming evidence against Mr. Sandusky."
In a bombshell announcement Thursday evening, Matt Sandusky -- one of Jerry Sandusky's six adopted children -- said through his attorney that he was sexually abused by the former Penn State assistant football coach, adding that he had been prepared to testify against him.