James Ellworth Rainerson, 63, was last seen on May 12.
According to the Arkansas State Police, Rainerson was last seen at his home on T.P. White Drive in Cabot as he left for the Walmart store in Heber Springs to pickup his medication.
Rainerson is reported to suffer from depression and alcoholism.
He was wearing a grey t-shirt and blue jeans when last seen.
Rainerson may be traveling in a black 2008 Ford F-150 Pickup truck with a black camper shell mounted on the bed. The license plate number is 692 JTW.
If you think you've seen Rainerson, call the Cleburne County Sheriff's Office at (501) 362-8143.