It happened just after 6 p.m. in the 5900 block of W. 19th Street.
Officers arrived on the scene to find Theodore Mitchell, 32, suffering from a stab wound to the neck. Paramedics rushed him to the hospital where he later died.
Authorities arrested 30-year-old Alisha Pearson as a suspect in the stabbing.
Witnesses told police the suspect and victim were in an argument moments before the stabbing occurred.